UNICAMPANIA
Prof. Nunzia D’Onofrio is the scientific responsible of the unit
Work plan
STUDY OF THE PROTECTIVE EFFECTS OF BIOACTIVES NANOCARRIERS IN ENDOTHELIAL PROGENITOR CELLS (EPC)
EVALUATE THE BENEFICIAL EFFECTS OF BIOACTIVE NANOCARRIERS ON VIABILITY, MIGRATION, HOMING AND VASCULOGENESIS OF EPC DERIVED FROM HUMAN PLURIPOTENT STEM CELLS (HPSCS).
DEFINE MOLECULAR MECHANISM(S) RESPONSIBLE FOR THE BIOACTIVE COMPOUND NANOCARRIERS ACTION ON EPC
UNICAMPANIA
The Department of Precision Medicine of University of Campania Luigi Vanvitelli (UNICAMPANIA) RU in the ENDO-CARE project will field its ability to exploit innovative technologies to define the pathogenesis of human diseases, allowing their molecular and genetic characterization, down to single cells. Prof. Nunzia D’Onofrio, scientific responsible of unit, has expertise in the study of molecules of biochemical interest and inflammatory mechanisms in the context of chronic degenerative diseases (cancer, cardiovascular diseases, diabetes, atherosclerosis), in the study of oxidative stress and epigenetic mechanisms underlying cardiovascular diseases with reference to endothelial and endothelial progenitor cell dysfunction in type 2 diabetes. UNICAMPANIA experience will allow to study in vitro the functional activity of bioactive nanocarriers on EPC. The UNICAMPANIA RU laboratories have advanced specialized instrumentation for biochemistry, cell biology, proteomics and metabolomics studies
