ISA - CNR
Research Unit (RU) is led by Dr. Carmela Spagnuolo (CNR-ISA). This RU includes mainly Dr. Carmela Spagnuolo, the PI, Dr. Annarita Formisano, and Dr. Francesco Mautone (research contract).
WORK PLAN
Evaluate the protective effects of bioactive nanocarriers in cellular models mimicking BBB dysfunctions
TO ASSESS THE EFFECTS OF BIOACTIVE NANOCARRIERS ON BBB INTEGRITY AND PERMEABILITY
TO STUDY THE PROTECTIVE EFFECTS OF BIOACTIVE NANOCARRIERS AGAINST OXIDATIVE STRESS- AND INFLAMMATORY-INDUCED BBB DYSFUNCTION
TO STUDY THE MOLECULAR MECHANISM(S) RESPONSIBLE FOR THE PROTECTIVE EFFECT ON BBB OF BIOACTIVE NANOCARRIERS
CNR - ISA
Research Unit (RU) is led by Dr. Carmela Spagnuolo (CNR-ISA). This RU includes Dr. Carmela Spagnuolo, the PI, and Dr. Annarita Formisano, plus a new unit to be hired (research contract). The RU interests focus mainly on the study of how natural compounds (extracts and pure molecules) exert a protective effect against degenerative pathologies, using in vitro (primary cells, cancer cell lines) and ex vivo cellular models (erythrocytes, PBMC, cancer cells isolated from patients). Studies on the chemopreventive and therapeutic activity of selected phytochemicals, such as quercetin, and on the neuroprotective potential of phenolic extracts were conducted, paying particular attention to the molecular mechanisms triggered. The RU CNR-ISA provides an excellent environment for participant laboratories in the program. Equipment and personnel expertise are available to conduct a broad spectrum of techniques in molecular and cellular biology, genetic and nutritional epidemiology, and protein science.
